Increase of forskolin-stimulaied cAMP accumulation by chronic treatment with amitriptyline in NG 108-15 cells
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Phosphatidylethanol Biosynthesis in Ethanol - exposed NG 108 - 15 Neuroblastoma X Glioma Hybrid Cells
12-0-Tetradecanoylphorbol-13-acetate (TPA) stimulates the release of free choline from intact NG10815 cells into the medium, without affecting the release of phosphocholine (Liscovitch, M., Blusztajn, J. K., Freese, A., and Wurtman, R. J. (1987) Biochem. J. 241, 81-86). To test the hypothesis that this response reflects activation of cellular phospholipase D, via protein kinase C (Ca’+/phosphol...
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15 صفحه اولAntisense targeting of delta opioid receptors in NG 108-15 cells: direct correlation between oligodeoxynucleotide uptake and receptor density.
Antisense oligodeoxynucleotides (ODN) have been used to inhibit the function of a number of structurally defined neurotransmitter receptors in vivo by transiently disrupting their expression in the CNS. However, issues concerning the cellular and molecular mechanisms of these ODN often raise questions about the specificity of such ODN-mediated "knock-down" of target proteins. This study sought ...
متن کاملP2Y2 receptor-Gq/11 signaling at lipid rafts is required for UTP-induced cell migration in NG 108-15 cells.
Lipid rafts, formed by sphingolipids and cholesterol within the membrane bilayer, are believed to have a critical role in signal transduction. P2Y(2) receptors are known to couple with G(q) family G proteins, causing the activation of phospholipase C (PLC) and an increase in intracellular Ca(2+) ([Ca(2+)](i)) levels. In the present study, we investigated the involvement of lipid rafts in P2Y(2)...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1995
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)46595-5